Distal Nerve Electrical Stimulation for Neuromuscular Reinnervation

Enrolling by invitation · Not applicable

Conditions studied: Electrical Stimulation, Peripheral Nerve Regeneration

In brief

During the process of nerve microsurgical reconstruction, 30 minutes of electrical stimulation is applied to the distal end of the damaged nerve to assess its potential benefits for nerve regeneration, functional recovery, slowing down the degeneration at the neuromuscular junction, and preventing muscle atrophy.

Key facts

Study ID

NCT06687460

Run by

National Cheng-Kung University Hospital

People needed

21

Starts

2024-09-12

Expected to finish

2027-12-31

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 and older
• Acute peripheral nerve rupture between the elbow and wrist
• Acute rupture of the median or ulnar nerve
• Patients who have signed a valid written consent for surgery and trials
• Patients with acute transection or compression of the median nerve or ulnar nerve resulting in impaired hand motor function.Patients with hand motor dysfunction secondary to nerve compression are defined as those who meet all of the following criteria:
• Evidence of muscle atrophy (including thenar muscles, hypothenar muscles, and interosseous muscles)
• Positive Froment's sign
• Positive Wartenberg's sign
• Presence of ape hand deformity
• Abnormal findings on electromyography (Needle EMG), such as abnormal insertional activity, increased spontaneous activity, or abnormal motor unit recruitment
• Classified as Grade IIA, IIB, or III according to the McGowan classification system for severity of nerve compression

You may not qualify if…

• History of injury or other causes leading to muscle and joint dysfunction in the affected area
• Patients with radial nerve damage
• Diabetes
• History of arrhythmia
• Stroke
• Multiple sclerosis
• Hereditary peripheral neuropathy
• Amyotrophic lateral sclerosis (ALS)
• Patients with a pacemaker
• Presence of local infection at the wound site
• Pregnant or breastfeeding women
• Patients deemed unsuitable for enrollment by a physician

Where it is running

• National Cheng Kung University Hospital — Tainan, Taiwan, Taiwan

Full record on ClinicalTrials.gov

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