Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer

Recruiting now

Conditions studied: Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty, Malnutrition, Sarcopenia, Chemobrain, Chemotherapy, Depression

In brief

The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery. Secondary objectives are to investigate the relationship between POD, preoperative depression, frailty, quality of life, malnutrition and sarcopenia. Participants identified with POD will be asked (at the routine follow-up meeting after surgery) to participate in an qualitative interview, in order to understand the participant's experience of postoperative delirium. The main objective aims to answer: What is the incidence of POD after gastroesophageal cancer surgery.

Key facts

Study ID: NCT06687291
Run by: Karolinska Institutet
People needed: 130
Starts: 2025-02-13
Expected to finish: 2027-11-11
Last updated by the study team: 2025-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients diagnosed with esophageal or gastric cancer, treated with (or without) chemotherapy and surgery.
Age ≥18 at the time for inclusion.
Participate on a voluntary basis and can (for any reason) end its participation during the study.
Capable of giving informed consent.

You may not qualify if…

Patients with preoperative cognitive dysfunction such as dementia.
Patients who are inoperable due to metastases.
Patients unable to communicate due to severely impaired hearing and/or - seeing.
Patients with ongoing drug and/or alcohol abuse.
Patients who cannot give informed consent.

Where it is running

Karolinska University Hospital, Huddinge — Huddinge, Sweden (enrolling)

Full record on ClinicalTrials.gov

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