cOncomitant Left Atrial aPpendage Closure and Pulsed Field ablaTION-Asia

Recruiting now

Conditions studied: Concomitant Procedures, Atrial Fibrillation, PFA, LAAC

In brief

Subjects enrolled in the OPTION-A study will be clinically indicated for atrial fibrillation (AF) ablation procedure with the FARAPULSE™ PFA system and treatment with WATCHMAN LAAC Device, per physician's medical judgement and according to hospitals' standard of care during the same procedure.

Key facts

Study ID

NCT06686485

Run by

Boston Scientific Corporation

People needed

433

Starts

2025-03-18

Expected to finish

2029-10-31

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically indicated for treatment with both the FARAPULSE™ PFA system and with WATCHMAN for LAAC, per physician medical judgement and as per hospitals' standard of care.
• Subjects who are willing and able to provide informed consent.
• Subjects who are willing and able to participate in all testing associated with this clinical study at an approved clinical investigational center.
• Subjects whose age is 18 years or above, or who are of legal age to give informed consent specific to state and national law.

You may not qualify if…

• Subjects who underwent prior AF ablation procedure.
• Subjects with atrial fibrillation that is secondary to electrolyte imbalance, thyroid disease, alcohol, or other reversible / non-cardiac causes.
• Already surgically closed or otherwise excluded LAA.
• The LAA anatomy does not accommodate a Closure Device.
• Known or suspected atrial myxoma.
• Presence of intracardiac thrombus.
• Subjects with a current interatrial baffle or patch, history of atrial septal repair or has an ASD/PFO device.
• Subjects with a presence of a mechanical valve prosthesis in any position.
• Subjects with a myocardial infarction within 30 days prior to enrollment.
• Subjects had a prior stroke (of any cause, whether ischemic or hemorrhagic) or transient ischemic attack (TIA) within the 90 days prior to enrollment.
• Any planned electrical cardioversion within 30 days following LAAC device implant.
• Subjects with a known inability to obtain vascular access.
• Subjects with any contraindication to percutaneous catheterization procedure (e.g., patient size does not accommodate required catheters, ventriculotomy or atriotomy), active conditions (e.g. infection, bleeding disorder, unstable angina) or congenital abnormalities (severe rotational anomalies of the heart or great vessels) are present*.
• Subjects with any active conditions (e.g. infection, bleeding disorder, unstable angina) are present.
• Subjects with any contraindications to short term use of anticoagulation therapy, or aspirin for conditions different from atrial fibrillation.
• Subjects who are pregnant or planning to be pregnant.
• Subjects with a life expectancy of ≤ 1 year per investigator's opinion.
• Subjects who are currently enrolled in another investigational study or registry that would directly interfere with the current study, except when the subject is participating in a mandatory governmental registry, or a purely observational registry with no associated treatments. Each instance must be reviewed by the sponsor to determine eligibility.

Where it is running

• Yokohama city minato Red Cross Hospital — Yokohama, Japan (enrolling)
• Pusat Jantung Sarawak — Kuching, Malaysia (enrolling)
• Asian Heart and Vascular Centre — Singapore, Singapore (enrolling)
• China Medical University Hospital — Taichung, Taiwan (enrolling)
• Taichung Veterans General Hospital — Taichung, Taiwan (enrolling)
• National Taiwan University Hospital — Taipei, Taiwan (enrolling)
• Taipei Veterans General Hospital — Taipei, Taiwan (enrolling)
• The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China (enrolling)
• Beijing Anzhen Hospital of the Capital University of Medical Sciences — Beijing, China (enrolling)
• Xuanwu Hospital Capital Medical University — Beijing, China (enrolling)
• Institute Jantung Negara — Kuala Lumpur, Malaysia (enrolling)
• The First Affiliated Hospital of Chengdu Medical College — Chengdu, China (enrolling)
• Guangdong Nanfang Hospital — Guangzhou, China (enrolling)
• The Third Affiliated Hospital of Guangzhou Medical University — Guangzhou, China (enrolling)
• The Affiliated Hospital of Guizhou Medical University — Guiyang, China (enrolling)
• Sir Run Run Shaw Hospital of Zhejiang University School of Medicine — Hangzhou, China (enrolling)
• QiLu Hospital of ShanDong University — Jinan, China (enrolling)
• First People's Hospital of Yunnan Province — Kunming, China (enrolling)
• Affiliated Hospital of Nantong University — Nantong, China (enrolling)
• Shanxi Cardiovascular Hospital — Taiyuan, China (enrolling)
• Zhuhai People's Hospital — Zhuhai, China (enrolling)
• Zigong First People's Hospital — Zigong, China (enrolling)
• Prince of Wales Hospital — Hong Kong, Hong Kong (enrolling)
• Princess Margaret Hospital — Hong Kong, Hong Kong (enrolling)
• Queen Mary Hospital — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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