Efficacy of Nerve Block Versus Botox in Chronic Migraine Management

Recruiting now · Not applicable

Conditions studied: Chronic Migraine, Chronic Migraine, Headache

In brief

The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic migraine in adults. The main questions it aims to answer are: * Do nerve block injections reduce the number of monthly migraine days compared to baseline? * Are there any differences in the frequency of migraine-related symptoms between the nerve block and Botox treatment groups? * Which treatment leads to higher patient satisfaction and improved quality of life? Participants in this study will: * Receive either nerve block injections or Botox injections every 12 weeks. * Visit the clinic once every month for follow-ups and assessments. * Maintain a headache diary to record the frequency and severity of their migraines and any adverse effects experienced. * Researchers will compare the outcomes of the two groups to determine if one treatment is superior in terms of efficacy and patient satisfaction.

Key facts

Study ID

NCT06684249

Run by

Zagazig University

People needed

64

Starts

2024-11-10

Expected to finish

2025-07-10

Last updated by the study team

2024-11-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 65 years.
• Diagnosis of chronic migraine, defined as having headaches on 15 or more days per month for more than three months, with at least 8 of those days meeting criteria for migraine.
• Ability to provide informed consent and comply with study requirements.
• No changes in prophylactic migraine medications in the last 3 months.

You may not qualify if…

• History of allergy or hypersensitivity to local anesthetics or Botulinum toxin.
• Previous nerve block or Botox treatment within the last 6 months.
• Significant comorbid psychiatric or neurological disorders that could interfere with study participation or evaluation.
• Pregnancy or breastfeeding.
• Contraindications to either treatment as per product labels.

Where it is running

• Zagazig University, Faculty of Medicine — Zagazig, Sharqia Province, Egypt (enrolling)

Full record on ClinicalTrials.gov

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