A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight

In brief

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to evaluate the effects of LY3549492 in adults with obesity or overweight. Participation in the study will last about one year.

Key facts

Study ID

NCT06683508

Run by

Eli Lilly and Company

People needed

288

Starts

2024-11-13

Expected to finish

2026-05-04

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• W8M-MC-GN01:
• Assigned male at birth
• Assigned female at birth, who are of non-childbearing potential
• W8M-MC-CWMM:
• Have a BMI of
• ≥ 30 kilograms per square meter (kg/m²) or
• ≥ 27 kg/m² and < 30 kg/m² with at least one weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss)

You may not qualify if…

• W8M-MC-GN01:
• Have Type 2 Diabetes Mellitus or Type 1 Diabetes Mellitus
• Have a history of acute or chronic pancreatitis
• Have renal impairment
• Individuals who are of childbearing potential
• W8M-MC-CWMM:
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening.
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have any of the following cardiovascular conditions within 3 months prior to screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure.
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have a lifetime history of suicide attempts.

Where it is running

• The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona, United States
• HOPE Research Institute — Phoenix, Arizona, United States
• Headlands Research - Scottsdale — Scottsdale, Arizona, United States
• The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson, Arizona, United States
• NorCal Medical Research, Inc — Greenbrae, California, United States
• Velocity Clinical Research, Huntington Park — Huntington Park, California, United States
• Peninsula Research Associates — Rolling Hills Estates, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Stamford Therapeutics Consortium — Stamford, Connecticut, United States
• Northeast Research Institute (NERI) — Fleming Island, Florida, United States
• Indago Research & Health Center, Inc — Hialeah, Florida, United States
• New Horizon Research Center — Miami, Florida, United States
• Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
• Charter Research - Winter Park — Orlando, Florida, United States
• Charter Research - Lady Lake — The Villages, Florida, United States
• Medical Research Partners — Ammon, Idaho, United States
• Great Lakes Clinical Trials - Andersonville — Chicago, Illinois, United States
• Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States
• NorthShore University Health System — Skokie, Illinois, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas, United States
• L-MARC Research Center — Louisville, Kentucky, United States
• Knownwell — Needham, Massachusetts, United States
• Lucida Clinical Trials — New Bedford, Massachusetts, United States
• Headlands Research - Detroit — Southfield, Michigan, United States

Full record on ClinicalTrials.gov

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