Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Recruiting now
Conditions studied: Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Chronic Rhinosinusitis (CRS)
In brief
The goal of this observational study is to learn more about the real-world efficacy of biologics in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). All patients who are 18 years or older, who have CRSwNP and are eligible for reimbursement of a biological for the indication of CRSwNP can be included. The main question is the efficacy of biologics in real life after 24 weeks. The main focus are patient reported outcomes measured via several questionnaires and the nasal polyp score, scored with nasal endoscopy.
Key facts
- Study ID
- NCT06683261
- Run by
- Universitaire Ziekenhuizen KU Leuven
- People needed
- 300
- Starts
- 2022-09-23
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2024-11-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participant must be at least 18 years of age at the time of signing the informed consent.
- Capable of giving signed informed consent.
- Participants should have CRSwNP.
- Participants should fulfil the reimbursement criteria for their prescribed biological (omalizumab, mepolizumab and/or dupilumab).
You may not qualify if…
- Patients treated with other biological therapies in the 3 months prior to the current biological (this is not applicable to patients who are in the trial and switch biological).
Where it is running
- Onze Lieve Vrouw hospital Aalst — Aalst, Belgium (enrolling)
- General hospital Sint-Jan Bruges — Bruges, Belgium (enrolling)
- University hospital Saint-Luc — Brussels, Belgium (enrolling)
- University hospital of Antwerp — Edegem, Belgium (enrolling)
- Hospital Zuid-Oost Limburg — Genk, Belgium (enrolling)
- University Hospital Brussels — Jette, Belgium (enrolling)
- University hospitals Leuven — Leuven, Belgium (enrolling)
- CHU de Liège — Liège, Belgium (enrolling)
Full record on ClinicalTrials.gov
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