Predict Tooth Wear

Recruiting now

Conditions studied: Prediction of Tooth Wear

In brief

Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully comprehend tooth structure loss until visible. Recently, statistical shape analysis (SSA) used to learn the tooth anatomy and define a reference shape (biogeneric tooth) using. However, assuring landmark consistency is challenging mostly due to biases of the operator. Recently, a robust method called MEG-IsoQuad offered automated, isotopological remeshing. Combining this with SSA holds promise for diagnostic and simulation purposes. This study aims to assess the reliability of a remeshing-SSA approach for altered and intact premolar analysis and compare machine learning algorithms for simulating the shape of the initially intact tooth or future altered one. The clinical perspective of the current work offers possibilities to: * Prevent future tooth wear by detecting it at an early stage; and communicate better to the patient by presenting him/her potential future altered teeth * Simulate the adapted reconstruction for the altered tooth by simulating the initially intact one

Key facts

Study ID

NCT06681844

Run by

Hospices Civils de Lyon

People needed

1000

Starts

2023-12-12

Expected to finish

2027-12-01

Last updated by the study team

2024-11-08

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• teeth avulsed presenting a tooth wear index between 0 and 3
• mature incisor, canine, premolar or molars (1st and 2nd only)

You may not qualify if…

• teeth avulsed presenting a tooth wear index over 3 (or presenting an oral rehabilitation representative of a similar wear)
• immature teeth or teeth without root edification
• wisdom teeth

Where it is running

• Indiana University Hospital — Indianapolis, Indiana, United States (enrolling)
• KU Leuven University Hospital — Leuven, Belgium (enrolling)
• Lyon Dental Hospital — Lyon, France (enrolling)
• King George Medical University — Lucknow, India (enrolling)
• Tel Aviv Universi — Tel Aviv, Israel (enrolling)

Full record on ClinicalTrials.gov

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