A Study to Assess Nomlabofusp in Adolescents and Children With Friedreich's Ataxia

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Friedreich Ataxia

In brief

The goal of this clinical trial is to evaluate the safety and tolerability of nomlabofusp (CTI-1601) in adolescents and children with Friedreich's ataxia (FRDA).

Key facts

Study ID

NCT06681766

Run by

Larimar Therapeutics, Inc.

People needed

18

Starts

2024-12-06

Expected to finish

2025-04-27

Last updated by the study team

2026-07-10

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject has genetically confirmed diagnosis of FRDA manifested by homozygous GAA repeat expansions, with repeat sizing (if available) included on the diagnosis report.
• Male or female subjects ≥ 2 to < 18 years of age at screening.
• Subjects must weigh ≥ 10.0 kg.
• Subject must be able to traverse a distance of 25 feet with or without some assistive device (e.g., cane, walker, crutches, self-propelled wheelchair) and meet the following requirements:
• Be able to sit upright with thighs together and arms crossed without requiring support on more than 2 sides;
• Be able to transfer from bed to chair independently or with assistance if, in the opinion of the investigator, the degree of physical disability does not result in undue risk to the subject while participating in the study; and
• Perform basic age-appropriate daily care, such as feeding themselves and personal hygiene, with minimal assistance.

You may not qualify if…

• Subjects who are confirmed as compound heterozygous (GAA repeat expansion on only 1 allele) for FRDA.
• Subject has any condition, disease, or situation, including a cardiac condition or disease, that in the opinion of the investigator could confound the results of the study or put the subject at undue risk, making participation inadvisable.
• Subjects currently receiving or having received omaveloxolone within 30 days prior to Screening.

Where it is running

• Uncommon Cures — Chevy Chase, Maryland, United States

Full record on ClinicalTrials.gov

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