Study of Normal Intestinal Development and Disease in Premature and Term Neonates

Recruiting now

Conditions studied: NEC, Necrotizing Enterocolitis, Intestinal Disease, Human Development

In brief

Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that some proteins and pathways that are critical in human development have no clear role in mice. This study aims to improve the overall understanding of critical aspects of intestinal development in humans. In addition, this study will investigate the impact of intestinal diseases that are found in the early stages of life such as necrotizing enterocolitis (NEC).

Key facts

Study ID

NCT06681129

Run by

Boston Children's Hospital

People needed

100

Starts

2025-03-17

Expected to finish

2034-12-31

Last updated by the study team

2026-03-27

Who can join

Age: any, up to 2. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any neonate or infant through 2 years of age having intestinal surgery or intestinal biopsies from an esophogastroduodenoscopy (EGD) or colonoscopy.

You may not qualify if…

• Children > 2 years of age.
• Infants 0-2 years old not undergoing GI surgery or intestinal scope with biopsy procedure.

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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