Breast Cancer Evolution During Neoadjuvant Systemic Therapy
Recruiting now
Conditions studied: Breast Cancer, Triple Negative Breast Cancer, ER+ Breast Cancer, HER2+ Breast Cancer
In brief
BELIEVE is a translational research study that aims to collect samples of breast cancer tissue and blood from individuals undergoing breast cancer treatment (such as chemotherapy, targeted therapy and immunotherapy) before surgery. In certain cases, MRI scans and stool samples will also be obtained before and during treatment. The samples collected from this study will be used for molecular and genetic research to understand why some cancers respond very well to anticancer treatments, and some do not, develop novel ways of accurately measuring response during treatment, as well as identify which patients are at a higher risk of the cancer coming back after surgery.
Key facts
- Study ID
- NCT06681064
- Run by
- Royal Marsden NHS Foundation Trust
- People needed
- 500
- Starts
- 2024-05-29
- Expected to finish
- 2034-05-01
- Last updated by the study team
- 2026-04-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed non-metastatic invasive breast cancer.
- Be suitable for, but have not commenced, neoadjuvant chemotherapy, targeted therapy, or immunotherapy.
- If HER2-, suitable for treatment with upfront taxane chemotherapy. If HER2+, suitable for treatment with anti-HER2 targeted therapy.
- Be aged 18 years and over.
- Have given written informed consent to participate.
You may not qualify if…
- Metastatic breast cancer at diagnosis.
- Treatment with neoadjuvant endocrine therapy only.
- Presence of any psychological, familial or sociological condition potentially hampering compliance with the study protocol and follow-up schedule.
Where it is running
- Royal Marsden NHS Foundation Trust — London, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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