A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Enrolling by invitation · Phase 3

Conditions studied: Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

In brief

The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

Key facts

Study ID

NCT06679946

Run by

Alnylam Pharmaceuticals

People needed

700

Starts

2024-12-03

Expected to finish

2028-03-31

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are participating in the patisiran parent studies ALN-TTR02-011 or ALN-TTR02-014 or who have completed the 24-month OLE Period in the vutrisiran parent study ALN-TTRSC02-003

You may not qualify if…

• Has permanently discontinued study drug administration while participating in the parent studies, ALN-TTR02-011, ALN-TTR02-014, or ALN-TTRSC02-003
• Future or current participation in another investigational device or drug study, scheduled to occur during this study
• Has other medical conditions or comorbidities which, in the opinion of the Investigator, would interfere with study compliance or data interpretation

Where it is running

• Clinical Trial Site — Beverly Hills, California, United States
• Clinical Trial Site — La Jolla, California, United States
• Clinical Trial Site — Stanford, California, United States
• Clinical Trial Site — Washington D.C., District of Columbia, United States
• Clinical Trial Site — Chicago, Illinois, United States
• Clinical Trial Site — Glenview, Illinois, United States
• Clinical Trial Site — Indianapolis, Indiana, United States
• Clinical Trial Site — Kansas City, Kansas, United States
• Clinical Trial Site — Baltimore, Maryland, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Rochester, Minnesota, United States
• Clinical Trial Site — St Louis, Missouri, United States
• Clinical Trial Site — Omaha, Nebraska, United States
• Clinical Trial Site — New York, New York, United States
• Clinical Trial Site — New York, New York, United States
• Clinical Trial Site — Durham, North Carolina, United States
• Clinical Trial Site — Cleveland, Ohio, United States
• Clinical Trial Site — Columbus, Ohio, United States
• Clinical Trial Site — Philadelphia, Pennsylvania, United States
• Clinical Trial Site — Nashville, Tennessee, United States
• Clinical Trial Site — Dallas, Texas, United States
• Clinical Trial Site — Salt Lake City, Utah, United States
• Clinical Trial Site — Buenos Aires, Argentina
• Clinical Trial Site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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