Neonatal Platelet Transfusion Threshold Trial
Recruiting now · Not applicable
Conditions studied: Thrombocytopenia, Neonatal, Platelet Transfusion, Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Thrombosis
In brief
The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).
Key facts
- Study ID
- NCT06676904
- Run by
- NICHD Neonatal Research Network
- People needed
- 2433
- Starts
- 2025-06-13
- Expected to finish
- 2031-04-30
- Last updated by the study team
- 2026-03-25
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Gestational age of 23 0/7 to 26 6/7 weeks
- Postnatal age of < 48 hours
You may not qualify if…
- Comfort care or withdrawal of care planned
- Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder
- Receipt of platelet transfusion
- No receipt of Vitamin K
- Parents/guardian decline consent
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- Stanford University — Palo Alto, California, United States (enrolling)
- Sharp Mary Birch Hospital for Women & Newborns — San Diego, California, United States (enrolling)
- University of Colorado — Aurora, Colorado, United States (enrolling)
- Emory University — Atlanta, Georgia, United States (enrolling)
- Northwestern Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
- University of Iowa — Iowa City, Iowa, United States (enrolling)
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
- University of New Mexico — Albuquerque, New Mexico, United States (enrolling)
- University of Rochester — Rochester, New York, United States (enrolling)
- Duke University — Durham, North Carolina, United States (enrolling)
- Cincinnati Children's Medical Center — Cincinnati, Ohio, United States (enrolling)
- Case Western Reserve University, Rainbow Babies and Children's Hospital — Cleveland, Ohio, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- Vanderbilt University — Nashville, Tennessee, United States (enrolling)
- University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States (enrolling)
- University of Texas Health Science Center at Houston — Houston, Texas, United States (enrolling)
- Pediatrix Medical Group — San Antonio, Texas, United States (enrolling)
- University of Utah — Salt Lake City, Utah, United States (enrolling)
Full record on ClinicalTrials.gov
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