Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen

Recruiting now · Not applicable

Conditions studied: Periodontal Diseases

In brief

To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen. The results will shed light on the clinical potential of VCMX in regenerative periodontal surgery and help to develop new treatment strategies.

Key facts

Study ID: NCT06676826
Run by: University of Bern
People needed: 80
Starts: 2025-09-01
Expected to finish: 2027-12-30
Last updated by the study team: 2025-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients with localized or generalized periodontitis Stage III and Stage IV, Grade A-B-C
Males and females
Age at least 18 years and older
Presence of interdental intra-bony defects (I, II and III walls) in either the maxilla or the mandible with a PD ≥ 6 mm
Defects with an intra-bony component \&gt; 3 mm for both groups
Intra-bony defect located only at one aspect (mesial or distal)
Presence of at least 2 mm of keratinized soft tissue. Exclusion Criteria
Patients with systemic disease that could interfere with periodontal wound healing
Prolonged antibiotic treatment or anti-inflammatory treatment within 4 weeks prior to surgery
Pregnant or lactating
Smokers with \&gt; 10 cig./day
Patients with FMPS and FMBS \&gt; 25 % after completion of non-surgical periodontal therapy
Multi-rooted teeth with furcation involvement
Third molars
Teeth with circumferential defects
Interdental craters
Written Informed Consent

Where it is running

University of Bern — Bern, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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