Open-label, Multi-center, Phase I/II Study to Assess Safety, Disease Progression and Cellular Kinetics Following YTB323 Administration in Participants With Non-active Progressive Multiple Sclerosis (PMS)
Recruiting now · Phase 1/Phase 2
Conditions studied: Progressive Multiple Sclerosis
In brief
This is an open-label, multi-center, non-confirmatory study to assess the safety, disease progression, and cellular kinetics following YTB323 administration to 28 participants with non-active Progressive Multiple Sclerosis (PMS). The study design utilizes an ascending single dose design consisting of 3 sentinel cohorts followed by an expansion cohort.
Key facts
- Study ID
- NCT06675864
- Run by
- Novartis Pharmaceuticals
- People needed
- 28
- Starts
- 2024-12-12
- Expected to finish
- 2030-06-14
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Novartis Investigative Site — Zurich, Switzerland (enrolling)
- Novartis Investigative Site — Melbourne, Victoria, Australia (enrolling)
- Novartis Investigative Site — Québec, Quebec, Canada (enrolling)
- Novartis Investigative Site — Bron, France (enrolling)
- Novartis Investigative Site — Montpellier, France (enrolling)
- Novartis Investigative Site — Nancy, France (enrolling)
- Novartis Investigative Site — Rennes, France (enrolling)
- Novartis Investigative Site — Essen, Germany (enrolling)
- Novartis Investigative Site — Mainz, Germany (enrolling)
- Novartis Investigative Site — Ulm, Germany (enrolling)
- Novartis Investigative Site — Genova, GE, Italy (enrolling)
- Novartis Investigative Site — Milan, MI, Italy (enrolling)
- Novartis Investigative Site — Barcelona, Spain (enrolling)
- Novartis Investigative Site — Madrid, Spain (enrolling)
- Novartis Investigative Site — Málaga, Spain (enrolling)
- Novartis Investigative Site — Darlinghurst, New South Wales, Australia (enrolling)
- Novartis Investigative Site — Lausanne, Switzerland (enrolling)
- Novartis Investigative Site — Bern, Switzerland
Full record on ClinicalTrials.gov
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