Fermented Papaya and Driving Simulator Older Adult Study

Completed · Not applicable

Conditions studied: Healthy

In brief

Yes, this additional detail will refine the original template content to emphasize the study's specific aims and hypotheses. Here's an updated version: The goal of this clinical trial is to assess if Fermented Papaya Preparation (FPP) can enhance driving performance and reduce driving errors in community-dwelling older adults aged 70-80, who serve as their own controls. The main questions it aims to answer are: Does FPP reduce the total number of driving errors, particularly those related to psychomotor performance? Does FPP improve driving-related cognitive functions, such as divided attention, working memory, reaction time, and executive function? How do FPP dosage, timing, and acute effects impact driving performance in adults aged 65 and older? Participants will: Consume three doses of FPP (3 grams per dose) within 24 hours, with the final dose administered before the simulator driving test. Complete a high-fidelity driving simulation to assess the association between FPP use and driving errors that predict on-road performance. Undergo baseline and post-FPP cognitive assessments to compare psychomotor performance and cognitive functions after FPP administration.

Key facts

Study ID

NCT06672874

Run by

University of Florida

People needed

34

Starts

2025-03-19

Expected to finish

2026-05-31

Last updated by the study team

2026-07-06

Who can join

Age: 70 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 70 and 80 years.
• Community-dwelling and independent in daily living activities.
• Holds a valid driver's license and has driven in the last 3 months.
• Proficient in reading, writing, and speaking English.
• Physically able to participate in a driving simulation.
• Willing to comply with the study requirements, including FPP dosing and simulator sessions.

You may not qualify if…

• Currently taking psychoactive medications.
• Diagnosed with a physical disability that impairs driving ability.
• History of upper extremity amputation or right lower extremity amputation.
• Scores below 18/30 on the Montreal Cognitive Assessment (MoCA).
• Exhibits symptoms of severe simulator sickness after an initial test session.

Where it is running

• UF Smarthouse — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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