Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest

Recruiting now · Not applicable

Conditions studied: Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation

In brief

Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA). The procedure consists of two defibrillators that administer shocks at the same time. Currently, the procedure is not initiated before at least three failed attempts with one defibrillator. This can delay the potential benefits of establishing DSED earlier in the treatment. Studies have shown that early defibrillation is crucial for survival in OHCA patients, and in 2022, a clinical trial showed that survival in patients treated with DSED was higher compared to standard treatment. The effect of initiating OHCA treatment is unknown. The DUALDEFIB trial seeks to investigate if treating OHCA patients with DSED as an initial treatment will increase survival and provide improved neurological outcome.

Key facts

Study ID

NCT06672159

Run by

St. Olavs Hospital

People needed

356

Starts

2025-04-28

Expected to finish

2028-10-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with out of hospital cardiac arrest presenting with a shockable rhythm

You may not qualify if…

• Age below 18 years
• Obvious or suspected pregnancy
• Incarcerated patients
• Preexisting do-not-resuscitate order

Where it is running

• St Olavs Hospital — Trondheim, Norway (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.