Evaluating a Fasting-mimicking Diet in Combination With Immunotherapy in Patients With Non-small Cell Lung Cancer
Recruiting now · Not applicable
Conditions studied: Stage IV NSCLC, NSCLC, Immunotherapy, Fasting Mimicking Diet
In brief
The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.
Key facts
- Study ID
- NCT06671613
- Run by
- VA Office of Research and Development
- People needed
- 66
- Starts
- 2025-10-27
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2025-11-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years at the time of informed consent
- Ability to provide written informed consent and HIPAA authorization.
- Eastern cooperative group (ECOG) performance status of 0 to 2
- Newly diagnosed histologically or cytologically confirmed stage IV Non-Small Cell Lung Cancer (NSCLC). Patients with locally advanced NSCLC that are not candidates for definitive therapy but are candidates for trial are allowed per investigator discretion.
- BMI 19 kg/m2
- Patients should be enrolled prior to starting standard of care immunotherapy for the treatment of stage IV NSCLC. Patients should be on PD (L)1 inhibitor alone (i.e., with PD-L1 expression 50%) in the metastatic setting. The investigators will allow single agent pembrolizumab only as the checkpoint inhibitor.
- Patients requiring palliative radiation or definitive radiation to an oligometastatic disease prior to the initiation of single agent checkpoint inhibitors are allowed once radiation has been completed and patients have recovered from toxicities.
You may not qualify if…
- Self-reported weight loss of > 10% in the 6 weeks prior to study entry
- History of symptomatic hypoglycemia or uncontrolled diabetes
- Prior therapies with inhibitors of insulin growth factor I(IGF-1) such as Linsitinib or Picropodophyllin
- Concurrent use of somatostatin
- Concurrent use of immunosuppressive medications including sirolimus, tacrolimus, mycophenolate mofetil, azathioprine, prednisone, dexamethasone, or cyclosporine
- Significant food allergies which would make the subject unable to consume the food provided.
- History or current evidence of any uncontrolled medical or psychiatric condition, therapy that may confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the participating subject as deemed by the treating investigator.
- Pregnant or lactating females are not eligible.
Where it is running
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California, United States (enrolling)
- Jesse Brown VA Medical Center, Chicago, IL — Chicago, Illinois, United States (enrolling)
- Richard L. Roudebush VA Medical Center, Indianapolis, IN — Indianapolis, Indiana, United States (enrolling)
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO — St Louis, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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