Treating Lid Wiper Epitheliopathy

Completed · Phase 4

Conditions studied: Dry Eye, Visual Acuity

In brief

Lid wiper epitheliopathy (LWE) is a relatively new entry into the abundance of clinical ocular surface health signs. LWE was first reported in 2002 as a potential cause for dry eye disease (DED) (Korb et al., 2002). This clinical sign is visualised by everting the eyelid after a dye has been applied and observing the palpebral conjunctiva proximal to the eyelashes

Key facts

Study ID

NCT06671041

Run by

Southern College of Optometry

People needed

52

Starts

2024-05-27

Expected to finish

2024-08-30

Last updated by the study team

2025-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ≥18 years of age
• best corrected visual acuity (BCVA) of 20/100 or better
• who have symptomatic DED will be recruited (SPEED ≥6)
• Subjects will also be required to have a LWE score of 1.0 or greater to be included in the study.
• Subjects will be required to discontinue contact lens wear throughout the study.

You may not qualify if…

• known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome),
• have a history of ocular surgery within the past 12 months, have a history of severe ocular trauma, active ocular infection or inflammation,
• are currently using Accutane or ocular medications, or if they are pregnant or breast feeding.
• Artificial tear use will be discontinued at least one week prior to enrollment. Subjects with a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation in the study will be excluded.
• Subjects that have had a physical meibomian gland treatment withing 1 month of enrollment (iLux, Lipiflow, etc.) will be excluded.
• Subjects will not be allowed to use any eye drops beyond their assignment during the study.

Where it is running

• Maitland Vision Center — Orlando, Florida, United States
• Complete Eye Care of Medina — Medina, Minnesota, United States
• Montaquila — Warwick, Rhode Island, United States
• The Southern College of Optometry — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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