Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
Recruiting now
Conditions studied: Syndecan 1, Severe Burn, Endotheliopathy of Trauma, Endothelial Glycocalyx, Hemorrhagic Shock, Postoperative Complications
In brief
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery. The main questions it aims to answer are: * Do severely burned patients present with EoT before undergoing burn debridement surgery? * Does the surgical intervention worsen EoT, leading to increased postoperative syndecan 1 (sdc 1) levels compared to preoperative levels? Participants will: * Undergo debridement surgery where the total area of debrided and donor sites covers 20% or more of the Total Body Surface Area (TBSA). * Have their sdc 1 levels measured before and after surgery. * Have perioperative factors analyzed to assess their impact on endothelial damage and glycocalyx functionality. This study aims to provide insight into how surgical resuscitation affects the endothelial glycocalyx in severely burned patients.
Key facts
- Study ID
- NCT06670248
- Run by
- Hospital Universitari Vall d'Hebron Research Institute
- People needed
- 40
- Starts
- 2024-03-05
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2024-11-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients over 18 years old with burned TBSA greater than or equal to 20%.
- Patients who will undergo debridement of at least 20% of the burned TBSA (including the debrided area and the donor site).
You may not qualify if…
- Under 18 years old.
- Pregnant women.
- Patient refusal.
- Polytraumatized patients.
- Electrical or chemical burns.
- Patients with any of the following pre-burn conditions: complicated heart disease*, renal disease on hemodialysis/hemofiltration or with Glomerular Filtration Rate (GFR) < 30 ml/min/1.73m², and liver cirrhosis (Child A, B, and C).
- (* Definition of complicated heart disease: decompensated heart failure (NYHA class IV), Left Ventricular Ejection Fractio < 40%, or severe valvular disease).
- Patients with a history of chronic inflammatory diseases (autoimmune disease).
- Patients on chronic treatment with corticosteroids or immunosuppressants.
- Patients requiring reintervention for debridement surgery who have already been included in the study during their first surgery.
Where it is running
- Hospital Universitari Vall d'Hebron — Barcelona, Spain, Spain (enrolling)
Full record on ClinicalTrials.gov
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