Personalized Post-Operative Pain Management

Running, not enrolling · Phase 4

Conditions studied: Persistent Post Operative Opioid Use, Post-surgical Pain

In brief

The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in opioid naïve patients after surgery? Participants will: Take hydromorphone if the PGx results determine they have a SNP indicating high or low metabolic activity in the CYP2D6 enzyme. Complete a 7-day pain diary post-discharge. Complete a follow-up phone call once per month for 90 days.

Key facts

Study ID

NCT06669650

Run by

University of Tennessee Graduate School of Medicine

People needed

208

Starts

2024-09-25

Expected to finish

2025-12-01

Last updated by the study team

2024-11-01

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-85 years of age 2.Able to read and understand study procedures. 3.Willing to participate and sign an ICF. 4.Opioid naïve 90 days prior to surgery.

You may not qualify if…

• <18 years of age and >85 years of age
• Unable to understand study procedures.
• Unwilling to give consent.
• Patients with cognitive impairment that can affect their ability to give consent.
• Previous Surgery <14 days from time of enrollment.
• Allergies to study intervention or oxycodone.

Where it is running

• The University of Tennessee Graduate School of Medicine — Knoxville, Tennessee, United States

Full record on ClinicalTrials.gov

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