Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3
Completed
Conditions studied: Cannabis, Memory, Electroencephalography
In brief
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of two different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.
Key facts
- Study ID
- NCT06669585
- Run by
- L. Cinnamon Bidwell
- People needed
- 96
- Starts
- 2024-10-09
- Expected to finish
- 2025-12-10
- Last updated by the study team
- 2026-05-12
Who can join
Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Must be between the ages of 21 and 40 and provide informed consent;
- Must be right-handed (Laterality Quotient > 60 on Edinburgh Handedness Inventory - Short Form);
- Must use cannabis at least 4 days during the month;
- Must be a cannabis user for at least a year;
- Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening;
- Must not test positive on a urine toxicology test for drugs of abuse at the Baseline appointment;
- Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days;
- Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless);
- Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours before each appointment;
- Must have a breath alcohol level of 0 at Baseline appointment (to sign consent form);
- Must not be actively seeking or in treatment for any substance use disorder;
- Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test administered at Baseline appointment);
- Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders;
- Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.
Where it is running
- Center for Innovation and Creativity (CINC) — Boulder, Colorado, United States
Full record on ClinicalTrials.gov
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