Effect of Force Magnitude on Canine Retraction and Gingival Crevicular Fluid Proteome

Recruiting now · Not applicable

Conditions studied: Tooth Crowding

In brief

This study aims to examine the effect of force levels in orthodontic treatment during canine retraction. Force levels refer to the pressure applied by the orthodontic devices to move teeth. Data collection will include gingival fluid, dental molds from a digital scanner, and x-rays of the upper canine region on both sides of the mouth during treatment. The null hypothesis to be tested is that there is no significant difference in the rate of canine movement between the light force and the heavy force levels.

Key facts

Study ID

NCT06668194

Run by

UConn Health

People needed

40

Starts

2024-11-13

Expected to finish

2028-04-01

Last updated by the study team

2024-11-26

Who can join

Age: 11 and older, up to 16. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy patient, non-smoker
• Age: 11 - 16 years of age, inclusive.
• A full complement of dentition (central incisor to 1st molar) in the four quadrants, except second molars
• Patients requiring at least upper bilaterally maxillary 1st premolar extraction as a treatment plan (Class I bimaxillary protrusion/ crowding or Class II maxillary dentoalveolar protrusion/ crowding)
• At least 5 mm of space left between canine and 2nd premolar to be closed at the time of canine retraction
• At least six months after the extraction of first premolars and in a 0.019 x 0.025-inch stainless steel archwire in the maxilla
• The ability to read and understand English and to provide informed consent

You may not qualify if…

• Patients under 11 years of age and over the age of 16.
• Non-extraction treatment plan
• Extraction of maxillary tooth other than first premolars bilaterally.
• Evidence of poor oral hygiene
• Evidence of previous root resorption
• Missing or impacted tooth in any of the quadrant except 3rd molars.
• Medical issues that affect tooth movement
• Inability to provide oral and written consent to participate.
• Patient on medications that may alter bone metabolisms like bisphosphonates, oral contraceptives, or PTH (parathyroid hormone)
• Chronic illness or syndromic patients.
• Pregnant women, prisoners, and decisional impaired

Where it is running

• Department of Orthodontics — Farmington, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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