A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity

Running, not enrolling · Phase 3

Conditions studied: Obesity

In brief

The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity. The study will last about 89 weeks.

Key facts

Study ID

NCT06662383

Run by

Eli Lilly and Company

People needed

800

Starts

2024-11-01

Expected to finish

2026-12-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight.

You may not qualify if…

• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90 days before screening.
• Have a prior or planned surgical treatment for obesity.
• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity.
• Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
• Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2).
• Have had within the past 90 days before screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)
• coronary revascularization
• hospitalization for unstable angina, or
• hospitalization due to congestive heart failure.
• Have New York Heart Association Functional Classification Class IV congestive heart failure.
• Have a history of chronic or acute pancreatitis.

Where it is running

• Mary & Dick Allen Diabetes Center — Newport Beach, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• Encompass Clinical Research — Spring Valley, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Lynn Institute of Denver — Aurora, Colorado, United States
• Bridgeport Hospital — Bridgeport, Connecticut, United States
• Yale University School of Medicine — New Haven, Connecticut, United States
• Encore Medical Research — Hollywood, Florida, United States
• Suncoast Research Group — Miami, Florida, United States
• Onhealth Research Center — Miami, Florida, United States
• Precision Clinical Research — Sunrise, Florida, United States
• Einstein Clinical Research — Vero Beach, Florida, United States
• ClinCept Clinical Research - MH — Columbus, Georgia, United States
• Northeast Georgia Medical Center — Gainesville, Georgia, United States
• Pivotal Research Solutions — Stonecrest, Georgia, United States
• East-West Medical Research Institute — Honolulu, Hawaii, United States
• Northwestern University — Chicago, Illinois, United States
• Integrated Clinical Trial Services, Inc. — West Des Moines, Iowa, United States
• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States
• Great Lakes Research Group, Inc. — Bay City, Michigan, United States
• Great Lakes Research Institute — Southfield, Michigan, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Las Vegas Endocrinology — Henderson, Nevada, United States
• Albany Medical College, Division of Community Endocrinology — Albany, New York, United States
• Medical Advancement Centers of Arizona — Tempe, Arizona, United States

Full record on ClinicalTrials.gov

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