Pre-exposure Prophylaxis (PrEP) Adherence for Black MSM

Starting soon · Not applicable

Conditions studied: HIV Prevention

In brief

The goal of this clinical trial is to learn if two interventions-C4 and C4+3MV-can improve PrEP adherence (taking medication to prevent HIV) among Black men who have sex with men (MSM). The study will also explore the most effective ways to support participants in continuing their PrEP use over time. The main questions it aims to answer are: * Does the C4 program help participants take PrEP more regularly? * Does adding the 3MV intervention to C4 provide additional support for adherence? Researchers will compare two intervention strategies to see if they result in better PrEP adherence: * C4 Intervention: A program focused on individualized care coordination and addressing structural needs. * C4 + 3MV Intervention: A combination of care coordination with additional behavioral change sessions. Participants will: * Participate in PrEP education and counseling sessions. * Have their PrEP use monitored through dried blood spot (DBS) tests. * Complete questionnaires about their experiences and challenges with PrEP. Receive support sessions tailored to address individual barriers to PrEP adherence.

Key facts

Study ID

NCT06661343

Run by

Yale University

People needed

500

Starts

2026-08-01

Expected to finish

2029-06-30

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Self-identify as male.
• Self-Identify as Black people.
• Aged 18 or older.
• Self Report having sex with men in the past 6 months.
• Eligible for PrEP or currently prescribed PrEP.
• Willing to participate in behavioral intervention sessions.

You may not qualify if…

• Currently diagnosed with HIV.
• Unable to provide informed consent.
• Unable to fully engage with the intervention due to health issues.
• Participating in another clinical trial with conflicting outcomes.

Where it is running

• Bronx Health Center — New York, New York, United States
• Abounding Prosperity, Inc. — Dallas, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.