A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)
Running, not enrolling · Phase 2
Conditions studied: Advanced Solid Tumor, Metastatic Solid Tumors
In brief
This pan-tumor trial is designed as a signal-seeking trial to assess efficacy and safety of raludotatug deruxtecan (R-DXd) monotherapy in locally advanced or metastatic solid tumors with various cadherin-6 (CDH6) expression levels, including gynecological cancers (endometrial cancer, cervical cancer, and non-high-grade serous ovarian cancer) and genitourinary cancers (urothelial cancer and clear cell renal cell carcinoma \[ccRCC\]).
Key facts
- Study ID
- NCT06660654
- Run by
- Daiichi Sankyo
- People needed
- 200
- Starts
- 2025-01-06
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Northside Hospital — Marietta, Georgia, United States
- University of Michigan Comprehensive Cancer Center Michigan Medicine — Ann Arbor, Michigan, United States
- Astera Cancer Care — East Brunswick, New Jersey, United States
- Women's Cancer Care Associates — Albany, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Clinical Research Alliance — Westbury, New York, United States
- West Cancer Center and Research Institute — Germantown, Tennessee, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- UZ Leuven Gynaec onco — Leuven, Belgium
- ZAS Sint-Augustinus — Wilrijk, Belgium
- Hunan Cancer Hospital — Changsha, China
- Shanghai Cancer center — Shanghai, China
- Herlev og Gentofte Hosp — Copenhagen, Denmark
- François Baclesse Center — Caen, France
- Centre Georges-François Leclerc — Dijon, France
- Centre Oscar Lambret — Lille, France
- Centre Leon Berard — Lyon, France
- Grp Hsp Diac Croix Saint Simon — Paris, France
- Cario - Centre Armoricain de Radiothérapie, Imagerie Médicale Et Oncologie — Plérin, France
- Ico - Site René Gauducheau — Saint-Herblain, France
- Institut Claudius Regaud — Toulouse, France
- Gustave Roussy — Villejuif, France
- AO per lEmergenza Cannizzaro — Catania, Italy
- Irccs Ospedale San Martino — Genova, Italy
- IRCCS Dino Amadori - IRST — Meldola, Italy
Full record on ClinicalTrials.gov
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