Intravenous Methocarbamol for Acute Pain After Spine Surgery

Completed

Conditions studied: Acute Post Operative Pain, Postsurgical Pain Management, Spine Surgery, Acute Pain, Postoperative, Multimodal Analgesia

In brief

The goal of this target trial emulation is to evaluate the impact of intravenous (IV) methocarbamol on postoperative pain and opioid use in adults undergoing elective spine surgery. The main questions it aims to answer are: * Does IV methocarbamol reduce pain in the 6 hours following surgery? * Does IV methocarbamol decrease the need for opioid pain medications in the same period? Participants who receive IV methocarbamol as part of their routine postoperative care will have their pain scores and opioid consumption tracked for 6 hours after treatment. Pain levels will be measured using standard assessments, and opioid use will be quantified in oral morphine equivalents.

Key facts

Study ID

NCT06659965

Run by

The University of Texas Health Science Center, Houston

People needed

1270

Starts

2020-01-01

Expected to finish

2025-06-30

Last updated by the study team

2025-11-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Undergoing one of the following three elective spine surgeries: (i) Anterior Cervical Discectomy and Fusion (ACDF), (ii) Posterior Spinal Fusion, or (iii) Laminectomy, Laminotomy, or Discectomy
• At least 8h of valid pain scores recorded postoperatively

You may not qualify if…

• Emergency Surgery
• Pregnancy
• Sensitivity to methocarbamol (allergy)
• End-stage renal disease (ESRD)
• Myasthenia gravis
• Missing a valid electronic anesthesia record

Where it is running

• Memorial Hermann Health System — Houston, Texas, United States

Full record on ClinicalTrials.gov

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