A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Alzheimer Disease, Healthy
In brief
The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY4006895. Part A will administer a single-ascending dose in healthy participants or Part B will administer multiple-ascending doses in participants with early symptomatic Alzheimer's Disease (AD). Blood tests will be performed to check how much LY4006895 gets into the bloodstream and how long it takes the body to eliminate it. This is a 2-part study and will last approximately 29 weeks for Part A and 61 weeks for Part B, including a screening period for each part.
Key facts
- Study ID
- NCT06657768
- Run by
- Eli Lilly and Company
- People needed
- 128
- Starts
- 2024-10-29
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-06-04
Who can join
Age: 45 and older, up to 85. Sex: any. Healthy volunteers: accepted.
Where it is running
- Collaborative Neuroscience Network - CNS — Los Alamitos, California, United States (enrolling)
- K2 Medical Research - The Villages — Lady Lake, Florida, United States (enrolling)
- K2 Medical Research — Maitland, Florida, United States (enrolling)
- Atlanta Center of Medical Research — Atlanta, Georgia, United States (enrolling)
- CenExel iResearch, LLC (CenExel iRA) — Decatur, Georgia, United States (enrolling)
- CenExel-HRI — Marlton, New Jersey, United States (enrolling)
- Duke Early Phase Research Unit — Durham, North Carolina, United States
- The University of Tokyo Hospital — Bunkyō City, Japan
- QUEST Research Institute — Farmington Hills, Michigan, United States
- National Center for Geriatrics and Gerontology — Ōbu, Japan
- Aqualane Clinical Research — Naples, Florida, United States
- Progressive Medical Research — Port Orange, Florida, United States
- K2 Medical Research - Tampa — Tampa, Florida, United States
Full record on ClinicalTrials.gov
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