Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study

Recruiting now · Not applicable

Conditions studied: Heart Failure - NYHA II - IV

In brief

PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany. For the randomised part, 750 patients will be randomized to care within a heart failure network or usual care. The primary endpoint of the randomized trial is change in NT-proBNP from baseline to 6 months of follow-up. All patients (randomized or not) will be followed for two years.

Key facts

Study ID

NCT06656832

Run by

University of Leipzig

People needed

1000

Starts

2024-11-28

Expected to finish

2028-12-31

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients admitted to the participating study centres with acute decompensated heart failure (ADHF), defined as clinical signs and/or symptoms of heart failure
• objective structural cardiac abnormalitites according to the ESC criteria.

You may not qualify if…

• Age <18 years
• pregnancy
• any condition interfering with the informed consent process
• patients placed in an institution by official or court order

Where it is running

• University Hospital Leipzig — Leipzig, Germany (enrolling)

Full record on ClinicalTrials.gov

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