A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

Epstein Barr virus (EBV) is a virus which can cause infectious mononucleosis and is associated with certain kinds of cancer and multiple sclerosis. Researchers are looking for new ways to prevent disease related to EBV and have developed a new study vaccine (V350A and V350B). The main goal of this study is to learn about the safety and tolerability of V350A and V350B in healthy adults.

Key facts

Study ID

NCT06655324

Run by

Merck Sharp & Dohme LLC

People needed

250

Starts

2024-12-05

Expected to finish

2028-07-17

Last updated by the study team

2026-07-24

Who can join

Age: 12 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The key inclusion criteria include but are not limited to the following:
• Is in good health before randomization.
• Has a body mass index between 18 and 38 kg/m\^2, inclusive, for adults 18-30; has a body mass index between 15 and 38 kg/m\^2, inclusive, for adolescents 12-17.

You may not qualify if…

• The key exclusion criteria include but are not limited to the following:
• Has a confirmed or suspected case of infectious mononucleosis within 12 months prior to enrollment.
• Has any immunosuppressive medical condition or receive any immunosuppressive therapy.

Where it is running

• Remington-Davis, Inc. ( Site 0017) — Columbus, Ohio, United States (enrolling)
• Lynn Health Science Institute ( Site 0010) — Oklahoma City, Oklahoma, United States (enrolling)
• Alliance for Multispecialty Research, LLC ( Site 0008) — Kansas City, Missouri, United States (enrolling)
• Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0016) — Springfield, Missouri, United States (enrolling)
• Velocity Clinical Research Lincoln ( Site 0004) — Lincoln, Nebraska, United States (enrolling)
• Velocity Clinical Research, Omaha ( Site 0005) — Omaha, Nebraska, United States (enrolling)
• Alliance for Multispecialty Research, LLC ( Site 0009) — Knoxville, Tennessee, United States
• QPS-MRA, LLC ( Site 0012) — South Miami, Florida, United States
• California Clinical Trials Medical Group managed by PAREXEL ( Site 0011) — Glendale, California, United States

Full record on ClinicalTrials.gov

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