A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
Recruiting now · Phase 1
Conditions studied: Gastrointestinal Stromal Tumor (GIST), Gastrointestinal Stromal Cancer, Gastrointestinal Stromal Neoplasm, Gastrointestinal Stromal Tumor, Malignant, Gastrointestinal Stromal Cell Tumors
In brief
In this clinical trial, the safety, tolerability, and preliminary antitumor activity of ziftomenib in combination with imatinib will be evaluated in adults with gastrointestinal stromal tumors (GIST) who have been treated previously with imatinib.
Key facts
- Study ID
- NCT06655246
- Run by
- Kura Oncology, Inc.
- People needed
- 157
- Starts
- 2025-03-27
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-02-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Texas — Houston, Texas, United States (enrolling)
- University of Texas Health Science Center — San Antonio, Texas, United States (enrolling)
- University of Utah — Salt Lake City, Utah, United States (enrolling)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- Mayo Clinic Cancer Center — Phoenix, Arizona, United States (enrolling)
- University of California, San Diego — La Jolla, California, United States (enrolling)
- University of Southern California — Los Angeles, California, United States (enrolling)
- University Of California, Irvine — Orange, California, United States (enrolling)
- Stanford Cancer Institute — Palo Alto, California, United States (enrolling)
- UCLA Santa Monica Medical Center — Santa Monica, California, United States (enrolling)
- University of Colorado Cancer Center — Aurora, Colorado, United States (enrolling)
- Sarah Cannon Research Institute — Denver, Colorado, United States (enrolling)
- Yale University School of Medicine — New Haven, Connecticut, United States (enrolling)
- Mayo Clinic Cancer Center — Jacksonville, Florida, United States (enrolling)
- University of Miami — Miami, Florida, United States (enrolling)
- Northwestern University — Chicago, Illinois, United States (enrolling)
- University of Iowa — Iowa City, Iowa, United States (enrolling)
- Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- Harvard University — Boston, Massachusetts, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States (enrolling)
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States (enrolling)
- Duke University Medical Center — Durham, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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