Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer
Running, not enrolling · Not applicable
Conditions studied: Hereditary Cancer Syndromes, Clinical Decision Support
In brief
The goal of this clinical trial is to see if a software platform can improve cancer screening in young adults with genetic risk for cancer. The trial will also help improve the software platform (Nest). The main questions it aims to answer are: * Do Nest users know more about their cancer risks and recommended care than non-users? * Do Nest users have less psychological distress than non-users? * Do Nest users share cancer risks with family and other doctors more than non-users? * Are Nest users more likely than non-users to have up-to-date care plans? Researchers will compare Nest users to non-users to see if the Nest users are more likely to do recommended cancer screening. Participants will: * Have a genetic counseling or follow up visit * Take a post-visit survey * Intervention arm only: use the Nest Patient Navigator * Complete screening and follow-up care recommended by doctors
Key facts
- Study ID
- NCT06654466
- Run by
- Nest Genomics
- People needed
- 100
- Starts
- 2026-02-10
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2026-07-16
Who can join
Age: 18 and older, up to 49. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 18-49 years, inclusive
- previous cancer genetic testing with a finding of a pathogenic or likely pathogenic variant resulting in an increased risk of cancer warranting clinical management.
- English-speaking and -reading
- Receiving care at Dana Farber Cancer Institute
- Not in active cancer therapy at the time of approach
You may not qualify if…
- Age <18 or >49 years
- Has not had genetic testing for hereditary cancer syndromes or has been tested but no pathogenic or likely pathogenic variant was identified.
- Non-English speaking and reading
- Not receiving care at Dana Farber Cancer Institute
- Active cancer with therapy in progress
Where it is running
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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