Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets
Recruiting now · Not applicable
Conditions studied: Tooth Loss
In brief
The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth extraction in molar sites. The main question it aims to answer is: Does healing time influence the histologic, clinical, and radiographic outcomes following socket grafting (alveolar ridge preservation) in periodontally compromised extraction sockets. Researchers will compare a healing time of 3 months to a healing time of 6 months (conventional healing duration) to see if a shorter duration is viable for implant placement. Participants will: Take a cone-beam computed tomography (CBCT) scan to prepare for the surgical procedure. Undergo tooth extraction and the extraction socket will be grafted with Bio-Oss Collagen® and a collagen membrane Bio-Gide® will be placed to stabilize the graft material. Return at 2 weeks for suture removal and either 3- or 6-months post-extraction for implant placement. Return at 2 weeks post-implant placement for suture removal, 3 months for prosthesis fabrication, 4 months for final prosthesis loading, and 1 year post-loading.
Key facts
- Study ID
- NCT06654141
- Run by
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- People needed
- 42
- Starts
- 2025-02-06
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2025-02-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or older
- ASA (American Society of Anesthesia) status I or II
- Need for molar extraction due to periodontal disease with or without chronic endodontic involvement, complying with the presentation of periodontitis stage III/IV
- Radiographic evidence of a bone dehiscence on at least one socket wall, where the height of the horizontal (suprabony) component of the defect (alveolar bone crest - cement-enamel junction) is >50% of the corresponding root length as measured on CBCT scans prior to extraction (Ben Amara et al., 2021)
- Radiographic evidence of at least 3 mm of residual bone wall height
- Presence of at least one adjacent tooth to the extraction site
- Treatment plan must include tooth replacement with an implant-supported fixed dental prosthesis
You may not qualify if…
- Extraction of multiple adjacent teeth
- Acute infection associated with the tooth to be extracted or with adjacent teeth
- Current smokers (>10 cigarettes per day)
- Uncontrolled diabetes mellitus (HbA1c >7.0)
- Any active oral or systemic acute infections
- Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area
- Diseases or medications that may compromise normal wound healing
Where it is running
- Shanghai Ninth People's Hospital — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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