fMRI and Opioid Abstinence

Recruiting now

Conditions studied: Drug Use Disorder, Opioid Dependence, Opioid-Related Disorders, Opioid Use, Opioid Abuse

In brief

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Key facts

Study ID

NCT06651333

Run by

Yale University

People needed

240

Starts

2024-12-12

Expected to finish

2029-11-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• recent initiation of methadone or buprenorphine at a clinic, program, or doctor within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);
• eligibility for MRI scanning;
• ability to commit to study visits.

You may not qualify if…

• current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
• current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
• severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore <30 (i.e., severe impairment)
• past or present history of intellectual disability, developmental disorder, or neurological disease;
• head trauma with loss of consciousness >30 min;
• organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

Where it is running

• Hartford Healthcare — Hartford, Connecticut, United States (enrolling)
• The APT Foundation — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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