Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease

Recruiting now · Not applicable

Conditions studied: Von Willebrand Disease (VWD)

In brief

WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis) recurrence in von Willebrand disease.

Key facts

Study ID

NCT06651255

Run by

University Hospital, Lille

People needed

66

Starts

2026-03-10

Expected to finish

2032-03-01

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females adults aged > 18 years
• With a constitutional von Willebrand Disease (according to the phenotypic criteria of the French Reference Center of von Willebrand Disease)
• With a GI bleeding [either overt (any hematemesis, any melena or hematochezia with at least a 2g/dL drop in hemoglobin) or occult (iron deficiency anemia with at least 2g/dL drop in hemoglobin)] with the presence of angiodysplasia or a negative finding on digestive conventional endoscopy OR with a severe epistaxis (requiring red blood cells transfusion or treatment with VWF concentrates)
• Be affiliated to a social security scheme
• Written informed consent obtained

You may not qualify if…

• Acquired von Willebrand Disease
• Presence of an inhibitor to VWF or a contra indication to VWF concentrates
• Contra-indication to videocapsule endoscopy
• Refusal of the procedures part of the study
• Pregnant women or breastfeeding
• Short-life expectancy
• Liver cirrhosis Child-Pugh C or diagnosed portal hypertension
• Cancer currently undergoing chemotherapy
• Inability to provide informed consent
• Patient under justice protection

Where it is running

• CHU Montpellier — Montpellier, France (enrolling)
• CHU Tours — Tours, Tours, France
• CHU Amiens — Amiens, France
• CHRU Brest — Brest, France
• Hôpital cardiologique Louis Pradel — Bron, France
• CHU Caen — Caen, France
• CH Chambery — Chambéry, France
• CHU Clermont-Ferrand — Clermont-Ferrand, France
• CHU Dijon — Dijon, France
• AP-HP Hôpital Kremlin Bicetre — Le Kremlin-Bicêtre, France
• AP-HM Hôpital Timone — Marseille, France
• CHU Nantes — Nantes, France
• CHU Rennes — Rennes, France
• CHU Rouen — Rouen, France
• CHU Strasbourg — Strasbourg, France
• CHU Lille — Lille, Nord, France
• CHU Toulouse — Toulouse, France

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.