AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

Recruiting now · Not applicable

Conditions studied: HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation

In brief

The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.

Key facts

Study ID

NCT06650995

Run by

Technical University of Munich

People needed

40

Starts

2026-02-01

Expected to finish

2027-06-30

Last updated by the study team

2025-12-26

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed heart failure with preserved ejection fraction
• Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)

You may not qualify if…

• Paroxysmal, long-persistent or permanent atrial fibrillation
• Clinically unstable coronary artery disease or acute coronary syndrome
• Physical and/or mental inability to perform exercise testing
• Prior ablation therapy
• Precapillary pulmonary hypertension at rest
• Intracardiac shunts
• Left ventricular ejection fraction <50%
• High-degree valve insufficiency or stenosis (greater than grade 1 at rest)

Where it is running

• Department of Medicine, Division of Prevention and Sports Medicine TU Munich — Munich, Germany (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.