A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™
Recruiting now · Not applicable
Conditions studied: Surgical Site Infection, Surgical Complication, Implant Infection, Implant Complication
In brief
Goal of the Clinical Trial: The purpose of this clinical trial is to learn whether Xperience™ surgical irrigation solution is more effective than a standard dilute povidone-iodine solution in reducing surgical site infections (SSIs) following implant-based breast reconstruction in female patients, aged 18 and older. It will also assess the safety and overall surgical outcomes when using Xperience™ compared to povidone-iodine. Main Questions the Study Aims to Answer: * Does the use of Xperience™ decrease the incidence of surgical site infections compared to povidone-iodine? * What are the differences in the rates of premature implant removal due to infection between patients treated with Xperience™ and those treated with povidone-iodine? * Are there fewer post-surgical complications with Xperience™ compared to povidone-iodine? Study Design: Participants in this study will be randomly assigned to receive either Xperience™ or a dilute povidone-iodine solution during their bilateral implant-based breast reconstruction. Only the research team will know which irrgiation is given- the participant will not know. Participant Will: * Undergo the surgical procedure using one of the two irrigation solutions. * Receive regular post-operative check-ups to monitor for signs of infection and other complications. * Have data collected on any post-surgical complications, the necessity for early implant removal, and overall surgical outcomes.
Key facts
- Study ID
- NCT06649890
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 224
- Starts
- 2025-06-30
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2025-08-07
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Older than 18 years old
- Willing to comply with all study-related procedures
- Available for the duration of the study
- Participants undergoing double mastectomy surgery followed by one of the following: (1) Immediate reconstruction with tissue expander placement, (2) Delayed reconstruction with tissue expander or implant placement, (3) Immediate reconstruction with implant placement, (4) Second-stage reconstruction with tissue expander to implant exchange
You may not qualify if…
- Participants unable to participate in follow-up visits
- Participants undergoing unilateral mastectomy
- Tissue expanders placed by a surgeon outside of the UNC Chapel Hill Hospital System
- Undergoing autologous reconstruction
- Participant is unable to provide signed and dated informed consent
- Unwilling or unable to comply with all study-related procedures.
- Known history of sensitivity or allergic reaction to any of the components of the Xperience™ irrigation solution or dilute povidone-iodine irrigation
- Participant with any conditions that would be a contraindication to receiving surgery such as contraindications to general anesthesia
- Pregnant, planning to become pregnant or breast feeding participants
- Individuals providing informed consent with any mental impairment or condition that would make them unable to properly consent without use of legally authorized representative (LAR) or additional participant protections.
- Incarcerated participants
Where it is running
- University of North Carolina at Chapel Hill Hospital — Chapel Hill, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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