TMS With Real-time E-field and EEG Source Imaging

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Healthy Volunteers Only

In brief

The goal of this study is to develop and validate an approach for accurate targeting and stimulation of brain networks using transcranial magnetic stimulation (TMS) using information from magnetic resonance imaging (MRI) data. This study requires two visits from each participant. In the first visit, the participant will be scanned by MRI scanners to collect data from the brain. Next, the data will be analyzed by the researcher to model the connections between different regions of the brain to determine the stimulation areas related to the so-called frontoparietal network. In the second visit, the participants will take four TMS sessions with different types of stimulations applied to the computed targets and complete a computer-based task named multi-source interference task. Electroencephalogram (EEG) data will be collected during the TMS stimulations and tasks. The main hypothesis is that applying TMS stimulations to the brain targets reduces the response time and response error in the tasks.

Key facts

Study ID

NCT06645613

Run by

Brigham and Women's Hospital

People needed

50

Starts

2026-03-01

Expected to finish

2029-09-01

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age greater than 18 and less than 65 years.
• Able to understand and give informed consent/assent.
• No prior neuropsychiatric, neurological disorders, epilepsy, or seizures.
• No metal implants.
• Absent of lesions or tumors from MRI scans.

You may not qualify if…

• The presence of a cardiac pacemaker or pacemaker wires.
• Metallic particles in the eye.
• Vascular clips in the head or previous neurosurgery.
• Prosthetic heart valves.
• Significant claustrophobia.
• Non-fixed metallic particles (shrapnel).
• Any magnetic metallic particles in the body.
• Failure to assure non-pregnant status.
• Failure to perform the task of lying still.

Where it is running

• MGH at the Navy Yard — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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