AI-Driven CTA Reconstruction for Intracranial LVO

Recruiting now · Not applicable

Conditions studied: Acute Ischemic Stroke, Artificial Intelligence (AI), Endovascular Thrombectomy, CT Angiography

In brief

Acute ischemic stroke (AIS) caused by intracranial large vessel occlusion (LVO) in the anterior circulation significantly contributes to stroke-related disability and mortality. Recent randomized controlled trials have demonstrated substantial benefits of endovascular thrombectomy (EVT) when patients are appropriately triaged beforehand. However, accurately orienting the 'missed segment' during EVT remains challenging. Guide-wires often fail to navigate through the occlusion or are mistakenly directed into the small tranches or even cause vessel rupture. To address this clinical need, the investigators developed an artificial intelligence (AI) algorithm to automate the reconstruction of CT angiography (CTA), focusing on the occluded LVO segment. To evaluate the clinical utility of this AI algorithm, the investigators propose a prospective, stepped-wedge cluster-randomized study to determine whether integrating our AI algorithm into AIS care flow can reduce the time for first pass of the thrombus by improving the visualization of the occluded segment on CTA. Physicians will assess patient eligibility for thrombectomy, and all selected patients will receive standard care according to current guidelines. This approach is expected to enhance patient treatment outcomes for endovascular thrombectomy by leveraging readily available data.

Key facts

Study ID

NCT06645405

Run by

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

People needed

174

Starts

2024-10-20

Expected to finish

2025-12-31

Last updated by the study team

2024-10-16

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or Female, 18 years of age or older.
• Patients who present with signs and/or symptoms concerning acute ischemic stroke.
• Patients who undergo noncontrast CT and CT angiography imaging.
• Patients determined to have an intracranial large vessel occlusion (including the internal carotid artery, middle cerebral artery M1 segment, and M2 segment), and eligible for endovascular treatment.

You may not qualify if…

• CT imaging with severe motion artifacts.

Where it is running

• Shanghai Sixth People's Hospital — Shanghai, China (enrolling)
• Shanghai Sixth People's Hospital — Shanghai, Shanghai Municipality, China

Full record on ClinicalTrials.gov

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