Progesterone-modified Natural Cycle for FET

Recruiting now · Phase 3

Conditions studied: Infertility, Female

In brief

Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.

Key facts

Study ID

NCT06644794

Run by

Shandong University of Traditional Chinese Medicine

People needed

336

Starts

2025-03-05

Expected to finish

2028-12-01

Last updated by the study team

2026-04-29

Who can join

Age: 21 and older, up to 44. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 21 to 44 years undergoing FBT
• Body mass index (BMI) 18-35 kg/m2
• Having regular ovulatory cycles

You may not qualify if…

• Untreated uterine adhesions
• Medical contraindications to estrogen and progesterone therapy
• Illnesses contraindicating assisted reproductive technology or pregnancy
• History of recurrent implantation failures (> 2 embryo transfer failures)

Where it is running

• Affiliated Hospital of Shandong University of Traditional Chinese Medicine — Jinan, Shandong, China (enrolling)

Full record on ClinicalTrials.gov

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