Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects

Recruiting now · Not applicable

Conditions studied: Healthy Participants, Retinal Oxygen Extraction

In brief

It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.

Key facts

Study ID: NCT06643403
Run by: Medical University of Vienna
People needed: 50
Starts: 2024-09-30
Expected to finish: 2026-01-31
Last updated by the study team: 2025-11-21

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Men and women aged between 18 and 80 years
Signed informed consent
Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
Nonsmokers

You may not qualify if…

Abuse of alcoholic beverages or drugs
Participation in a clinical trial in the 3 weeks preceding the study
Symptoms of a clinically relevant illness in the 3 weeks before the first study day
Blood donation during the previous 3 weeks
Pregnant or breast-feeding women

Where it is running

Department of Clinical Pharmacology, Medical University of Vienna, Austria — Vienna, State of Vienna, Austria (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.