nTMS for Negative Symptom in Schizophrenia
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Schizophrenia
In brief
This research aims to test the effectiveness of Navigated transcranial magnetic stimulation (nTMS) of left Supramarginal Gyrus for negative symptoms. In this double-blind, randomized controlled trial, patients will be assigned to active iTBS experimental group or sham iTBS group. Treatment will last for 10 days, and data will be collected at baseline, 1 day and 1 month after treatment.
Key facts
- Study ID
- NCT06642675
- Run by
- Central South University
- People needed
- 40
- Starts
- 2024-11-22
- Expected to finish
- 2026-03-01
- Last updated by the study team
- 2025-12-05
Who can join
Age: any, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1.Clinical diagnosis of schizophrenia according to ICD-11.
- 2.Confirmation of the diagnosis of schizophrenia using the SCID-5-RV (DSM-5 Structured Clinical Interview for DSM-5 Disorders - Research Version).
- 3.Score more than 4 points on either item of negative symptoms (N1-N7).
- 4.Aged less than 60 years.
You may not qualify if…
- 1.Clinical diagnosis or SCID-5-RV assessment confirming neurodevelopmental disorders, bipolar and related disorders, substance use disorders (excluding alcohol and tobacco).
- 2.Presence of severe or acute physical illnesses, including traumatic brain injury, intracranial space-occupying or infectious diseases, acute cardiovascular diseases, acute respiratory system diseases, acute hematological disorders, etc.
- 3.Presence of clearly defined genetic diseases, including tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, Klinefelter syndrome (47,XXY), etc.
- 4.Contraindication for MRI examination or rTMS, such as metal implantation in the body, epilepsy, cochlear implants, etc.
- 5.Severe risk of self-injury or suicide
- 6.Other conditions where the researchers find unsuitable for the treatment
Where it is running
- Mental Health Institute of Second Xiangya Hospital,CSU — Changsha, Hunan, China (enrolling)
Full record on ClinicalTrials.gov
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