Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas

Recruiting now

Conditions studied: Head Neck Cancer, Oropharyngeal Neoplasms

In brief

Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.

Key facts

Study ID: NCT06642324
Run by: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
People needed: 550
Starts: 2024-04-30
Expected to finish: 2025-09-30
Last updated by the study team: 2024-12-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patient Age: adult (> 18 years)
Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC).
Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue)
Patient's Consent

You may not qualify if…

Patient Age: children (< 18 years)
Cancers of any part of the body other than the head-neck region.
People without HNSCC
Any chronic diseases, genetic diseases, acute/chronic infectious diseases, etc. -

Where it is running

Bangabandhu Sheikh Mujib Medical University (BSMMU) — Dhaka, Dhaka Division, Bangladesh (enrolling)

Full record on ClinicalTrials.gov

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