Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
Recruiting now
Conditions studied: Sudden Cardiac Arrest, Sudden Cardiac Death
In brief
The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented. Currently, for young victims (under 35 years) of SCA/SCD, no etiology is found in 40 to 50% of cases after a standard medical assessment, leading to two important consequences. For the victim's family, it is difficult to understand and accept this tragic event, and the risk of it occurring in another family member is a source of concern. Medically, the absence of a known cause limits the ability to effectively prevent such events. The RESOUDRE study will be a national, prospective, observational registry of young victims (12-35 years) of sports-related SCA/SCD. All cases will undergo the recommended etiological assessment, including autopsy for SCA cases, along with whole exome genetic analysis and toxicological testing. In the event a genetic pathology is identified, a genetic evaluation will be offered to other family members, and appropriate medical care will be provided if necessary. The results of this study could significantly reduce the number of unexplained sport-related SCA/SCD cases and aid in preventing these incidents among affected families.
Key facts
- Study ID
- NCT06642168
- Run by
- Rennes University Hospital
- People needed
- 80
- Starts
- 2024-10-11
- Expected to finish
- 2028-01-11
- Last updated by the study team
- 2025-01-08
Who can join
Age: 12 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Victims of SCA:
- Aged between 12 and 35 years
- No known cardiovascular pathology
- Experienced a sudden and non-traumatic SCA during or within one hour of participating in sports activities (leisure, training, or competition)
- For resuscitated victims (SCA group): A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, organs, or authorities responsible for assisting or representing them if they are unable to express their wishes).
- For non-resuscitated victims (SCD group): A person who has not formally objected to the reuse of their medical data during their lifetime.
- First-Degree Relatives:
- A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, bodies, or authorities responsible for assisting or representing them if they are unable to express their wishes).
- Non-Inclusion Criteria:
- For resuscitated SCA cases, individuals weighing less than 20 kg
- Victims or legal representatives who are subject to legal protection or deprived of their liberty
Where it is running
- CHU de Nice — Nice, France (enrolling)
- CHU Rennes — Rennes, France, France (enrolling)
- CHRU Tours — Tours, France (enrolling)
- CHU Bordeaux — Bordeaux, France
- CHU Brest — Brest, France
- CHU Caen — Caen, France
- CHU Clermont-Ferrand — Clermont-Ferrand, France
- APHP Hôpital Henri-Mondor — Créteil, France
- CHU Dijon Bourgogne — Dijon, France
- CHU de Grenoble Alpes — Grenoble, France
- CHRU Lille — Lille, France
- Hospices Civils de Lyon — Lyon, France
- APHP Hôpital Bichat — Paris, France, France
- CHRU Montpellier — Montpellier, France
- CHRU Nancy — Nancy, France
- CHU Nantes — Nantes, France
- APHP Hôpital Pitié-Salpêtrière — Paris, France
- CHU Poitiers — Poitiers, France
- CHU Reims — Reims, France
- CHU Rouen — Rouen, France
- CHU Saint-Etienne — Saint-Etienne, France
- CHRU Strasbourg — Strasbourg, France
- CHU Toulouse — Toulouse, France
- APHM Hôpitaux universitaires de Marseille — Marseille, France
- APHP Hôpital Européen Georges Pompidou — Paris, France, France
Full record on ClinicalTrials.gov
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