White Matter Plasticity in Schizophrenia

Recruiting now · Not applicable

Conditions studied: Schizophrenia Disorders

In brief

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Key facts

Study ID

NCT06641297

Run by

University of Maryland, Baltimore

People needed

36

Starts

2025-01-02

Expected to finish

2026-12-31

Last updated by the study team

2026-02-20

Who can join

Age: 15 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
• age 15-45
• able to provide informed consent

You may not qualify if…

• contraindications to MRI (metal implants, claustrophobia)
• medical condition that limits use of hands (ie, arthritis)
• Active or recent (within 6 months) substance use disorder other than nicotine

Where it is running

• Maryland Psychiatric Research Center — Catonsville, Maryland, United States (enrolling)
• University of Maryland Baltimore - Maryland Psychiatric Research Center — Catonsville, Maryland, United States

Full record on ClinicalTrials.gov

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