Integrated Treatment for Opioid Use Disorder and PTSD

Recruiting now · Not applicable

Conditions studied: Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)

In brief

This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone). Interested participants will complete a 10-12 week therapy, and be asked to complete surveys.

Key facts

Study ID

NCT06641115

Run by

Medical University of South Carolina

People needed

76

Starts

2025-03-01

Expected to finish

2027-08-01

Last updated by the study team

2025-11-28

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any gender; any race or ethnicity; aged 18-70 years old.
• English-speaking
• Meet DSM-5 diagnostic criteria for OUD.
• Meet DSM-5 diagnostic criteria for PTSD and have some memory of their index traumatic event.
• Must be maintained on a stable dose of medication for OUD for at least 1 month.
• Participants taking psychotropic medications will be required to be maintained on a stable dose for at least 1 month before study initiation.

You may not qualify if…

• Participants presenting with psychiatric contraindications (e.g., unmanaged psychosis or mania, or bipolar) will be excluded and referred clinically.
• Participants considered an immediate suicide risk, with current suicidal ideation and a plan of intent, or displaying other high-risk behaviors (i.e., MOUD refusal, risky fentanyl use, etc.), as determined by the PI and study team. These individuals will complete a safety plan and be referred for treatment.
• Participants meeting DSM-5 criteria for a concurrent, non-opioid, substance use disorder and who report that the other substance is their primary substance of use. These participants will be referred clinically for treatment.
• Participants enrolled in ongoing evidence-based psychotherapy for substance use disorders or PTSD outside of medications for OUD and standard psychotherapy groups in treatment programs.
• Medical problems requiring immediate and intensive treatment, such as unstable or symptomatic end stage liver disease.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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