Feasibility of Accelerated, Personalized rTMS as an Adjuvant for Impulse Control Disorders: a Pilot Study

Recruiting now · Phase 1

Conditions studied: Impulse Control Disorder

In brief

To learn if accelerated rTMS (repetitive transcranial magnetic stimulation) can be used as a possible therapy for excessive eating.

Key facts

Study ID

NCT06639594

Run by

M.D. Anderson Cancer Center

People needed

30

Starts

2024-11-21

Expected to finish

2027-11-03

Last updated by the study team

2026-03-23

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21 to 60
• BMI>30 (confirmed at in person visit)
• Able to follow verbal and written instructions in English and complete all aspects of the study.
• Have an address and telephone number where they may be reached.
• Subjects must report current stable residence. Stable residence is a domicile in which an individual can operate as if it were their own homestead and does not include shelters, halfway houses, treatment centers, or group homes.
• Meet safety criteria for EEG and rTMS.
• Willing and able to independently remove any metal from the neck and above for rTMS procedures (e.g., jewelry, retainer)
• Provides written informed consent and agree to all assessments and study procedures.
• Agrees to complete telehealth (live audio-video conference and phone) and in-person visits and to be contacted via text.

You may not qualify if…

• rTMS exposure for treatment or research purposes in the last 6 months.
• History of seizure, epilepsy, syncope, fainting episode, or head trauma resulting in loss of consciousness.
• Presence or history of neurological disorders (migraine, stroke, Alzheimer's Disease and other Dementias, Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury (TBI), increased intracranial pressure).
• History of brain surgery, implanted electronic device, metal in the head.
• Cardiac pacemakers, neural stimulators, implantable defibrillator, implanted medication pumps or sensors, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes)
• History of or currently under medical care for myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke, or transient ischemic attack.
• Reported history of vision problems that are not treated.
• Has a hairstyle not compatible with the EEG net that is required to be worn on the scalp during the experimental procedure.
• Reports current diagnosis or history of type I diabetes.
• Currently using insulin.
• Have undergone bariatric surgery.
• Currently being enrolled in a weight loss program
• Takes any prescription or over the counter medications or supplements to control weight and/or appetite.
• Self-report a history of or current diagnosis of a mental health condition.
• Reports insomnia (<4 hours sleep per night, in 3 or more nights per week in the last 3 months)
• Reports (<4 hours of sleep) the day of the visit.
• Reports using marijuana on a daily basis.
• Reports having used any other illicit drugs (other than marijuana) or prescription medications for non-medical reasons in the last 12 months.
• Currently receiving treatment for substance use disorder (e.g., alcohol, opioids, cocaine, marijuana, or stimulants).
• Females who report averaging more than 7 alcoholic drinks, or males who report averaging more than 14 alcoholic drinks in a single week in the last 30 days.
• Current use of certain medications (last 3 months):
• Investigational drugs.
• Drugs of anti or pro-convulsive action. Medications with psychotropic effects (e.g., antidepressants, antipsychotics).
• Medications known to increase risk of seizure taken within 1 week of enrollment.
• Smoking cessation medication (e.g., Zyban, Wellbutrin, Wellbutrin SR, Chantix).

Where it is running

• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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