PrEP Readiness Interventions for Sustained Motivation (PRISM)

Recruiting now · Not applicable

Conditions studied: HIV, Methamphetamine Disorders

In brief

This is a hybrid type I randomized controlled trial to test the effectiveness of contingency management (CM) alone versus CM with motivational interviewing (MI) for optimizing entry or re-entry into the HIV prevention or care continua. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via telehealth. Monthly follow-up assessments will be completed over 12 months to examine effectiveness MI+CM for the primary outcome - filling a pre-exposure prophylaxis (PrEP) or anti-retroviral therapy (ART) prescription (verified using a digital photo). Secondary outcomes will include: self-reported PrEP or ART clinical evaluation by a provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).

Key facts

Study ID

NCT06637436

Run by

Florida International University

People needed

400

Starts

2025-01-28

Expected to finish

2028-04-30

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older
• Assigned male a birth
• Self-reported methamphetamine use in the past 3 months
• HIV-negative or unknown serostatus at baseline
• Has not filled a PrEP prescription in the past 6 months

You may not qualify if…

• Unwilling or unable to provide informed consent

Where it is running

• Florida International University — Miami, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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