Immune Status After Being on Call for 24 Hrs

Recruiting now

Conditions studied: Sleep Deprivation

In brief

Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes. Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.

Key facts

Study ID

NCT06636318

Run by

University of Chicago

People needed

60

Starts

2024-10-17

Expected to finish

2027-12-01

Last updated by the study team

2025-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy subjects
• Surgery residents in a 24-hour shift rotation
• Gender of subjects: Males and females
• Age of subjects: 18 years old and older
• Racial and Ethnic Origin: Any race or ethnicity

You may not qualify if…

• Unwilling/unable to sign informed consent
• Vulnerable Subjects/Subject Capacity to provide consent

Where it is running

• The University of Chicago — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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