The Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Subjective Tinnitus

Recruiting now · Not applicable

Conditions studied: Tinnitus

In brief

The aim of this study is to compare the efficacy of frequency-specific patterned repetitive transcranial magnetic stimulation (rTMS) and 1Hz rTMS for the treatment of chronic subjective tinnitus. In this single-blind randomized controlled study, patients will be randomly assigned 1:1 to receive two different types of rTMS stimulation.

Key facts

Study ID

NCT06635967

Run by

Eye & ENT Hospital of Fudan University

People needed

120

Starts

2024-05-21

Expected to finish

2025-12-30

Last updated by the study team

2024-10-10

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged between 18 and 80 years old.
• Experiencing persistant subjective tinnitus for at least 3 months.
• A score of 38 or more on THI.
• 50 dB HL or less on the average pure tone threshold (0.5, 1, 2kHz) of the worse ear.
• Voluntarily participate in the study and sign the informed consent form.
• Have normal mental status and cognitive function, and be able to cooperate with the research process.

You may not qualify if…

• Diagnosis of Meniere's disease, conductive hearing loss or objective tinnitus.
• History of epilepsy or stroke.
• Diagnosis of acoustic neuroma.
• Severe sensorineural hearing loss.
• Surgically or traumatically implanted ferromagnetic foreign bodies, including but not limited to pacemakers, neurostimulators, prosthetic metal heart valves, aneurysm clips (non-titanium alloy), intraocular metal foreign bodies, cochlear implants, metal prostheses, metal joints, fixed steel plates or steel pins.
• Patients with active metal foreign bodies (metal implants, dentures, contraceptive rings), insulin pumps, etc., who have been evaluated in detail and are at risk for rTMS treatment.
• Patients taking vestibular sedatives, antipsychotics, anxiolytics, antiepileptics, and ototoxic drugs.
• Patients with a recent history of alcohol or drug abuse
• Bell's palsy
• Acute ear infection within the last 1 month
• Inability to cooperate or complete the study process
• Participation in another clinical trial within the last month.
• Have any condition that may affect compliance or safety
• Any other condition that, in the opinion of the investigator, makes enrollment in the study inappropriate.

Where it is running

• Eye & ENT Hospital of Fudan University — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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