Trancranial Pulse Stimulation on Anterior Insula Cortex and Dorsal Anterior Cingulate Cortex
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Healthy Adults
In brief
Transcranial pulse stimulation (TPS) is a newly developed non-invasive brain stimulation (NIBS) technique from Austria \& Germany with highly promising applicability in neuropsychiatric disorders. Clinical trials have shown a beneficial effect of TPS in patients with Alzheimer\'s disease and depression. Although TPS has the capability to noninvasively target deeper brain regions such as the dorsal anterior cingulate cortex (dACC) and anterior insula cortex (AIC), no TPS study has been conducted to investigate the feasibility and effectiveness of dACC or AIC stimulation. Here, a randomized, single-blind, sham-controlled clinical pilot trial is proposed to probe the effects of TPS over bilateral dACC and AIC on modulating cognitive, behavioral and emotional functions and functional connectivity of brain circuits.
Key facts
- Study ID
- NCT06635161
- Run by
- The Hong Kong Polytechnic University
- People needed
- 66
- Starts
- 2024-08-05
- Expected to finish
- 2025-12-30
- Last updated by the study team
- 2025-07-01
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18 to 65
- Biological and mental health, based on a clinical interview
- Able to understand and follow instructions by the study team
You may not qualify if…
- Major internal diseases, neurological disorders, or mental disorders
- Having a metal implant in the brain
- Corticosteroid treatment within 6 weeks prior to inclusion
- Pregnancy or breastfeeding
- Common NIBS and MRI exclusion criteria, such as a history of brain surgery, cardiac pacemaker, deep brain stimulation, and intracranial metallic particles
- Previous TPS experience
- Color blindness
Where it is running
- The Hong Kong Polytechnic University — Hong Kong, Hung Hom, Kowloon, Hong Kong (enrolling)
Full record on ClinicalTrials.gov
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